The Skinny Confidential Him & Her Show

The Key To Eliminating Inflammation, Supplement Quality, & How To Perform As Your Best Self Ft. Angelo Keely CEO of Kion

October 31, 2025

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  • Omega-3 fatty acids (EPA and DHA) are the most nutritive addition to a diet for lowering inflammation because they actively speed up the healing process rather than just stopping inflammation. 
  • The most important metric for omega-3 benefit is the percentage they make up of red blood cell walls (aiming for 8% to 12%), which improves cardiovascular health by making blood cells more flexible. 
  • When building a supplement cabinet, focus on foundational, consistently beneficial products like high-quality protein/essential amino acids, creatine, and Omega-3s, and be skeptical of highly targeted, new supplements based on limited research. 
  • Increasing the proportion of omega-3s in cell walls makes them more fluid, which is associated with a lower incidence of stroke and heart attack. 
  • Fish oils must be in the triglyceride form, as the ethyl ester form is significantly less bioavailable (up to 70% less) and is an older, chemically processed version. 
  • Adherence and consistency are the most important factors for supplementation success, and amino acids stimulate protein synthesis even on non-exercise days. 

Segments

Guest Introduction and Context
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(00:00:24)
  • Key Takeaway: Angelo Keely is returning to The Skinny Confidential Him & Her Show for the fourth time to focus on foundational supplements and routines.
  • Summary: The episode welcomes Angelo Keely, CEO of Kion, for his fourth appearance on The Skinny Confidential Him & Her Show. Previous discussions covered aminos, muscle building, weight loss, and diet. This episode aims to dive deeper into foundational supplements and routines that make a long-term difference.
Omega-3s and Inflammation
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(00:04:30)
  • Key Takeaway: Omega-3s (EPA and DHA) are unmatched in their ability to lower inflammation by creating pro-resolving mediators that actively heal tissue.
  • Summary: The simplest answer for why omegas are needed is their unparalleled ability to lower inflammation. Omega-3s, specifically EPA and DHA, make up a portion of red blood cell walls, improving flexibility and cardiovascular health. Unlike drugs that just stop inflammation, omega-3s contain metabolites that speed up the healing process, allowing inflammation to resolve entirely.
Inflammation’s Impact on Health
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(00:07:05)
  • Key Takeaway: Chronic inflammation negatively impacts all aspects of health, from major diseases like cancer to vanity concerns like skin and hair quality.
  • Summary: Chronic inflammation acts as a drain on the body’s resources, distracting it from necessary healing and maintenance functions. This systemic inflammation can be measured via biomarkers like C-reactive protein and is strongly correlated with cardiovascular disease, dementia, and cancer. While acute inflammation at an injury site is healthy, chronic, low-grade inflammation from modern lifestyle factors is detrimental.
Omega Ratio vs. Absolute Levels
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(00:08:40)
  • Key Takeaway: The absolute amount of omega-3s in the blood (measured in red blood cells) is more critical for reducing inflammation than the historical focus on the omega-6 to omega-3 ratio.
  • Summary: While the ratio was once emphasized, current understanding shows that the percentage of omega-3s in the red blood cell wall is key. The typical American level is only 4%, whereas an ideal level is 8% to 12%. Achieving these higher levels requires consuming significant servings of fatty fish or consistent supplementation.
Supplement Philosophy and Quality
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(00:13:35)
  • Key Takeaway: Kion focuses on developing foundational supplements that are worth taking consistently every day because they provide tangible, long-term benefits.
  • Summary: The company’s product development is intentionally focused on staples that the CEO wants to take daily for himself and his family, rather than chasing the newest, trendiest supplement. This approach builds a sustainable business model based on integrity and products that genuinely improve a customer’s life over time. Consumers should prioritize quality over cost for daily supplements, as cheap, low-potency products are often a waste of money or potentially harmful.
Risks of Poor Quality Omegas
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(00:19:02)
  • Key Takeaway: Consuming rancid or oxidized omega oils creates the risk of introducing more inflammation into the body, in addition to causing unpleasant fish burps.
  • Summary: The biggest risk with low-quality omega supplements is that the oil is already rancid and oxidized before ingestion. This oxidized oil can actively promote inflammation, similar to repeatedly reused cooking oils. High-quality omegas, like Kion’s, remain clean and fluid even when refrigerated, verifying their freshness.
Foundational Supplements vs. Niche Products
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(00:20:06)
  • Key Takeaway: Consumers often make the mistake of chasing new, niche supplements instead of focusing on well-studied, foundational health pillars like protein, creatine, and omega-3s.
  • Summary: A common mistake is stacking supplements based on Instagram marketing rather than a thoughtful approach aligned with personal goals. Supplements with long-standing research, such as quality protein/amino acids, creatine, and omega-3s, should be prioritized over highly targeted, new solutions. Collagen, for example, is highly marketed but lacks robust, non-industry-sponsored research supporting its fundamental benefits.
Omega-3s and Longevity Data
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(00:50:09)
  • Key Takeaway: Higher omega-3 levels in the blood are strongly correlated with living approximately five years longer and negate some negative mortality risks associated with smoking.
  • Summary: Large population studies show that individuals with lower omega-3 levels have a 15% higher rate of dying between ages 65 and 75. Smokers who maintained high omega-3 levels had similar mortality risk profiles to non-smokers who did not take omegas, demonstrating the anti-inflammatory benefits can counteract some negative habits. The best outcome, however, is achieved by not smoking while maintaining high omega-3 intake.
Omega-3s and Vessel Fluidity
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(00:53:24)
  • Key Takeaway: Omega-3s increase the flexibility of red blood vessels, potentially lowering stroke and heart attack incidence.
  • Summary: Cell walls made of saturated fats are stiff, while those made of omega-3s are more fluid. Increasing omega-3 proportion in red blood vessels makes them more flexible, similar to adding stretchy material to fabric. This increased fluidity is linked to a significantly lower incidence of stroke and heart attack.
Jones Road Beauty Product Review
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(00:54:28)
  • Key Takeaway: The Jones Road Beauty Miracle Bomb is a clean, multifunctional product acting as highlighter, blush, and bronzer.
  • Summary: The Miracle Bomb, in the All Natural shade, provides a light-reflecting, warm glow when applied to cheeks and above the lip. All Jones Road Beauty products are clean, meaning they are free from phthalates, sulfates, PEGs, or BPA. Listeners can receive a free Cool Gloss with code SKINNY.
Mizzen+Main Performance Wear
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(00:56:03)
  • Key Takeaway: Mizzen+Main offers timeless menswear featuring performance fabrics that are machine-washable and wrinkle-resistant.
  • Summary: The brand focuses on classic menswear designed to look effortless while achieving a vision of success. Their hero product, the Leeward dress shirt, uses original performance fabric suitable for all occasions. They also offer high-stretch pants and lightweight wool blazers.
The Skinny Confidential Candle Creation
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(00:57:36)
  • Key Takeaway: The Skinny Confidential candle was created due to concerns over toxic wicks causing respiratory issues in newborns.
  • Summary: The creator developed a non-toxic candle after noticing her baby coughing when traditional candles were lit, suspecting toxic wicks. This clean candle uses only three ingredients, including organic eucalyptus oil and an all-natural cotton wick. Listeners receive 20% off at shopskinnyconfidential.com until November 1st.
Supplementation for Children
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(00:59:08)
  • Key Takeaway: Kion Aminos are an excellent way to supplement children’s daily protein intake, and high-quality fish oil capsules can be chewed or mixed into food.
  • Summary: Mango Aminos are used for children by mixing scoops into water, rebranded as ‘candy water.’ Creatine is suggested as optional for kids, but increasing daily amino acids and omega-3s are fundamental. High-quality Kion omegas do not taste fishy and can be chewed or mixed into yogurt or food.
Fish Oil Quality Differentiation
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(01:01:03)
  • Key Takeaway: Triglyceride form fish oils are vastly superior to ethyl ester forms due to significantly higher bioavailability.
  • Summary: Ethyl ester is an older, chemical process form that is up to 70% less bioavailable than the triglyceride form, which naturally occurs in fish. Pharmaceutical drugs often use the ethyl ester form, leading copycat supplement companies to use this deficient format. High-quality fish oil should have omega-3s constituting approximately 80% or more of the total fat content.
Supplement Timing and Flavors
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(01:02:24)
  • Key Takeaway: Taking Kion Aminos before and with exercise enhances their effect due to increased blood flow, but consistency is paramount even on rest days.
  • Summary: The host’s routine involves taking omegas first, then Aminos with creatine before the gym, and seven amino pills later. Aminos should be taken daily to stimulate protein synthesis, even when not exercising. Available amino flavors include Mango (sweet spot), Watermelon (sweetest with a spicy aftertaste), Berry, and Lime (least sweet/most tart).