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[00:00:00.160 --> 00:00:11.040] Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance.
[00:00:12.000 --> 00:00:18.080] I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
[00:00:18.080 --> 00:00:20.240] Today, I have the pleasure of introducing Dr.
[00:00:20.240 --> 00:00:23.920] Samer Hattar as my guest on the Huberman Lab podcast.
[00:00:23.920 --> 00:00:25.840] And now, my conversation with Dr.
[00:00:25.840 --> 00:00:27.440] Samer Hattar.
[00:00:27.440 --> 00:00:30.240] Samer, thanks for sitting down with me.
[00:00:30.240 --> 00:00:31.040] My pleasure.
[00:00:31.040 --> 00:00:41.520] You are best known in scientific circles for your work on how light impacts mood, learning, feeding, hunger, sleep, and these sorts of topics.
[00:00:41.520 --> 00:00:49.520] So maybe you could just weigh us into what the relationship is between light and these things like mood and hunger, etc.
[00:00:49.760 --> 00:00:50.400] Sure.
[00:00:50.720 --> 00:00:54.800] So, I mean, you do appreciate the effect of light for vision.
[00:00:54.800 --> 00:01:00.800] So, when you wake up in a beautiful area, beautiful ocean, light is essential.
[00:01:00.800 --> 00:01:02.960] The sunrise, the sunset.
[00:01:02.960 --> 00:01:05.920] So, that's your conscious perception of light.
[00:01:05.920 --> 00:01:11.360] But light has a completely different aspect that is independent of conscious vision.
[00:01:11.360 --> 00:01:15.600] And that's how it regulates many important functions in your body.
[00:01:15.600 --> 00:01:20.800] I think the best that is well studied and well-known is your circadian clock.
[00:01:20.800 --> 00:01:26.000] And the word circadian comes from the word circa, which is approximate, and DN is day.
[00:01:26.000 --> 00:01:27.440] So, it's an approximate day.
[00:01:27.440 --> 00:01:29.360] Why is it an approximate day?
[00:01:29.360 --> 00:01:45.760] Because if I put you or any other human being who have a normal circadian clock in a constant condition with no information about feeding time, about sleep time, about what time it is outside, you still have a daily rhythm, but it's not exactly 24 hours.
[00:01:45.760 --> 00:01:51.800] So, it will shift out of the solar day because it's not exactly 24 hours, and hence the name circadio.
[00:01:52.000 --> 00:01:54.880] How does that rhythm show up in the tissues of our body?
[00:01:54.880 --> 00:01:57.760] It shows up at every level that we know we studied.
[00:01:57.760 --> 00:02:03.640] It shows up at the level of the cell, it shows up at the level of the tissue, and it shows up at your behavior.
[00:01:59.600 --> 00:02:06.600] The most obvious for you is your sleep-wake cycle.
[00:02:06.920 --> 00:02:10.920] You sleep and you're awake and sleep at the 24-hour rhythms.
[00:02:10.920 --> 00:02:15.080] The period length of the sleep rhythm on average is 24.2 hours.
[00:02:15.080 --> 00:02:20.760] So you'll be drifting 0.2 hours every day out of the solar day if you don't get the sunlight.
[00:02:20.760 --> 00:02:25.720] So the sunlight adjusts that approximate day to an exact day.
[00:02:25.720 --> 00:02:31.160] So now your behavior is adjusted to the light-dark environment or the solar day.
[00:02:31.160 --> 00:02:34.440] It's part of the brain that is not consciously driven.
[00:02:34.440 --> 00:02:37.560] So you actually do not know when it happens or when it doesn't happen.
[00:02:37.560 --> 00:02:46.040] And that's what we'll get into when I tell you why light affects your mood and why sometimes people don't know how to deal with light to improve their mood, for example.
[00:02:46.040 --> 00:02:46.840] What's the relevance?
[00:02:46.840 --> 00:02:48.840] I mean, why should we care about that short difference?
[00:02:48.840 --> 00:02:49.960] So let's do the math.
[00:02:49.960 --> 00:02:54.040] If you shift out 0.2 hours a day in five days, you're shifting out one hour.
[00:02:54.040 --> 00:02:58.920] So you're literally one hour off in your social behavior in five days.
[00:02:58.920 --> 00:03:01.000] In 10 days, you're two hours off.
[00:03:01.000 --> 00:03:09.320] And if you're an organism that is living in the wild, shifting out of the right phase of the cycle, you could either miss food or you could become food.
[00:03:09.320 --> 00:03:11.560] So it's really essential for survival.
[00:03:11.560 --> 00:03:20.680] I think it's one of the strongest aspects of survival for animals to have the anticipation and the adjustment to the solar cycle.
[00:03:20.680 --> 00:03:25.320] What is the machinery that allows that to happen?
[00:03:25.320 --> 00:03:27.960] And how does that machinery work?
[00:03:27.960 --> 00:03:34.840] Yeah, so we knew that in mammals, including us, we are mammals, humans, that the eyes are required for this function.
[00:03:34.840 --> 00:03:43.000] So, if humans are born without eyes or the optic nerves are damaged, humans are not able to adjust to the solar cycle.
[00:03:43.000 --> 00:03:44.960] So, we know that the eyes are required.
[00:03:44.960 --> 00:03:48.800] In the human retinas, there are two types of photoreceptors.
[00:03:44.600 --> 00:03:51.600] They are called rods and cones because of their shapes.
[00:03:51.920 --> 00:04:04.400] And these rods and cones simply take the photon energy, which light is made of, and they change it in a way to an electrical signal that allows us to build the image of the environment in our cortices.
[00:04:04.400 --> 00:04:13.120] However, people have found, including me with the work of David Burson and Ignacio Provencio, that there is a subset of ganglion cells.
[00:04:13.120 --> 00:04:19.360] The ganglion cells are the cells that leave the retina, their axon, leave the retina, and project to the brain.
[00:04:19.360 --> 00:04:25.680] So, these were thought to only relay rod and cone information from the light environment to the brain.
[00:04:25.680 --> 00:04:33.600] We found that a small subset of these ganglion cells are themselves photoreceptors that were completely missed in the retina.
[00:04:33.600 --> 00:04:54.000] And these are the photoreceptors that relay light environment subconsciously to the areas in the brain that have and house the circadian clock or the circadian pacemaker, which adjusts all the clocks in our bodies to the central brain clock that allows them to entrain to the 24-hour light-dark cycle.
[00:04:54.000 --> 00:04:58.160] So, these are cells that connect the eye of the brain that behave like photoreceptors, essentially.
[00:04:58.160 --> 00:05:16.720] I think it's worth mentioning now that people who are pattern vision blind, so people who cannot see but have eyes, many of them still have these cells, these melanops and intrinsically photosensitive cells, and can essentially match or entrain, as we say, onto the light-dark cycle.
[00:05:16.720 --> 00:05:20.000] In fact, they possibly have no problems in circadian photo entrainment.
[00:05:20.000 --> 00:05:22.160] They'll have enormous sleep-wake cycle.
[00:05:22.160 --> 00:05:23.200] But they're totally blind.
[00:05:23.200 --> 00:05:24.800] But they are totally image-blind.
[00:05:24.800 --> 00:05:36.040] And what's really interesting is that, and this story I heard from Chuck Seisler, so I'll give him credit: that some of these people who are image blind usually they get dry eyes and they give them a lot of pain.
[00:05:36.360 --> 00:05:42.600] And doctors used to think, oh, since they are image blind and they're getting dry eye, why don't you just remove their eyes?
[00:05:42.600 --> 00:05:44.200] They're not using them anymore.
[00:05:44.200 --> 00:05:58.440] And the minute they would remove their eyes, they start having cyclical sleep problems, indicating that now they are not in training to the light-dark cycle and are having cyclical jet lags when their clock shifts through the light-dark cycle.
[00:05:58.440 --> 00:05:59.560] That's really interesting.
[00:05:59.560 --> 00:06:12.760] And I hear from a number of blind people, a lot of them have issues with sleep, I think, in part because they don't realize that they too need to see light at particular times of day or night in order to absolutely.
[00:06:12.760 --> 00:06:18.600] What is the proper way to interact with light in the first part of the day?
[00:06:18.600 --> 00:06:20.920] Honestly, I think the easiest thing is waking up.
[00:06:20.920 --> 00:06:22.280] Get as much light as you can.
[00:06:22.360 --> 00:06:23.160] To your eyes.
[00:06:23.160 --> 00:06:24.360] Yeah, it's really nice.
[00:06:24.360 --> 00:06:25.720] Your system is primed.
[00:06:25.720 --> 00:06:27.800] If you're entrained, it's primed to get light.
[00:06:27.800 --> 00:06:29.240] The sun should be out.
[00:06:29.240 --> 00:06:34.760] Even when it's cloudy, you're going to get enough intensity to help you adjust your cycle to the day-night cycle.
[00:06:34.760 --> 00:06:37.800] These are general rules of thumb, but how long do you recommend people go out?
[00:06:38.120 --> 00:06:40.600] If you do it daily, I would say 15 minutes.
[00:06:40.600 --> 00:06:42.920] If you don't do it daily, you may want to increase it.
[00:06:42.920 --> 00:06:44.600] You do it more, it doesn't hurt.
[00:06:44.600 --> 00:06:48.520] And I'll tell you, if you're sensitive, you don't even have to go in the sun.
[00:06:48.520 --> 00:06:49.800] You could be in the shade.
[00:06:49.800 --> 00:06:52.920] There's going to be so many photons out there in the shade.
[00:06:52.920 --> 00:06:54.280] It's going to be perfect.
[00:06:54.280 --> 00:06:54.520] Okay.
[00:06:54.520 --> 00:07:09.800] And if for some reason one finds themselves very far north and it's very, very dense cloud cover, how long and at what point should somebody consider using an artificial light source to mimic the sunlight?
[00:07:09.800 --> 00:07:17.680] Yeah, honestly, this is where we don't have a lot of information still, because this is where we're going to discuss this maybe in more detail.
[00:07:17.840 --> 00:07:24.960] That if you put humans in artificial conditions, the circadian system is very sensitive to light.
[00:07:25.280 --> 00:07:34.960] But in reality, in the real environment, light also is affecting other aspects that are independent of the setting of the circadian base maker.
[00:07:34.960 --> 00:07:35.280] Okay.
[00:07:35.280 --> 00:07:39.520] And these, which we call the direct effect of light on mood, for example.
[00:07:39.520 --> 00:07:43.360] So that is very hard to figure out what intensity you need to use.
[00:07:43.360 --> 00:07:47.840] And we haven't done enough experiments because the system has been discovered just recently.
[00:07:47.840 --> 00:07:57.440] But yeah, I mean, if you're honestly, if you're that far north and you're in the winter and you want to make sure you don't use these light boxes, I would suggest that personally.
[00:07:57.440 --> 00:08:01.120] Okay, so I think we've nailed down that first part of the day.
[00:08:01.120 --> 00:08:08.720] Basically, it's get 10 to 30 minutes, depending on how bright it is, and try and do that as often as possible to give the system a regular daily is the best.
[00:08:08.720 --> 00:08:15.040] This system is really about, and you'll see that even for the effect on depression, it's about multiple days.
[00:08:15.680 --> 00:08:20.320] So you don't have to worry if you missed it one day, you know, stay longer if you want.
[00:08:20.320 --> 00:08:24.560] But if you're in a hurry and you want to do other stuff, that's a great recommendation.
[00:08:24.560 --> 00:08:27.680] So you might want to compensate with some extra time if you missed a day or two.
[00:08:27.680 --> 00:08:32.800] I've heard you say before it's entirely possible to get severely jet lagged without traveling.
[00:08:32.800 --> 00:08:33.600] Absolutely.
[00:08:33.600 --> 00:08:36.960] Simply by staying in, being on your phone too much, not getting the sunlight.
[00:08:36.960 --> 00:08:38.880] And you saw this during the pandemic.
[00:08:38.880 --> 00:08:43.280] A lot of people mentioned that their sleep-wake cycles suffered a lot.
[00:08:43.600 --> 00:08:56.080] Because if you're not going out and if you're staying at home and you don't have big windows and you're waking late, waking up late, and then you're using very bright light till late at night, your body is going to shift.
[00:08:56.080 --> 00:09:04.760] And now, your day is going to start instead of like really when the sun comes up, let's say at six o'clock in the morning, it's gonna your day is gonna start at 11 o'clock in the morning.
[00:09:04.920 --> 00:09:08.360] That's what your body's gonna think is the beginning of the day.
[00:09:08.680 --> 00:09:18.120] So, then you're not gonna be able to sleep at 10 o'clock at night because now that's really for your body is completely different timing.
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[00:12:14.240 --> 00:12:29.760] There is this idea of chronotypes that we all each intrinsically have a best rhythm of either being a morning person, you called yourself an early person, or a night owl, or more of a kind of standard, you know, to bed around 10:30, up around 7 type thing.
[00:12:29.960 --> 00:12:44.200] And the and I think there are now good data, correct me if I'm wrong, from the National Institutes of Mental Health and elsewhere showing that the more we deviate from that intrinsic rhythm, the more mental health issues and physical health issues start to crop up.
[00:12:44.200 --> 00:12:48.120] So, there is great data on this, and there's a couple of things that complicate this.
[00:12:48.120 --> 00:12:51.400] The first is the people who usually are late.
[00:12:51.400 --> 00:12:53.160] What do you mean, people that wake up late and go to sleep?
[00:12:53.400 --> 00:13:04.120] Go to sleep late and wake up late, they have an overwhelmingly higher level of depression because human notice that people who go to sleep early and wake up early, they do better in life.
[00:13:04.120 --> 00:13:05.960] They notice that they just perform better.
[00:13:05.960 --> 00:13:11.080] They perform, but the question is: is that intrinsic to the system or is that society?
[00:13:11.080 --> 00:13:13.720] Because society starts things usually early or late.
[00:13:13.720 --> 00:13:14.680] That's a hard question.
[00:13:14.680 --> 00:13:16.360] We discriminate against late rises.
[00:13:16.680 --> 00:13:18.120] In a way, we discriminate.
[00:13:18.120 --> 00:13:22.600] And I'm not so sure that the circadian system is that variable in the human population.
[00:13:22.600 --> 00:13:29.880] I mean, clearly, there are maybe some genetic factors that make a small percentage of like everything with a bell shape.
[00:13:29.880 --> 00:13:33.640] But I think most of the time the light environment may play a role.
[00:13:33.640 --> 00:13:38.280] And once, as you, as we've talked about, this is a long-term effect of light.
[00:13:38.280 --> 00:13:47.800] Once you get into a rhythm, it's hard to break out of that rhythm because if you start sleeping late and waking up late, you're not getting the morning sunlight.
[00:13:47.800 --> 00:13:48.200] Right.
[00:13:48.440 --> 00:13:50.680] And so, you're just going to be late.
[00:13:50.680 --> 00:14:05.960] It seems to me the case is that the only way to really know if you're meant to be an early bird, as they call it, an early person or a late person, or somewhere in between, is to get morning sunlight and figure out whether or not that makes you feel better.
[00:14:05.960 --> 00:14:12.920] So, what should people do in the afternoon/slash evening time in terms of their light viewing behavior?
[00:14:12.920 --> 00:14:17.840] I mean, the best thing to do is to let the natural light creep in into darkness, right?
[00:14:17.840 --> 00:14:19.360] That would be the best.
[00:14:14.760 --> 00:14:21.760] But clearly, that would be inefficient.
[00:14:21.840 --> 00:14:28.160] You want to go home, you want to read, you want to talk to your kids, you want to talk to your family.
[00:14:28.160 --> 00:14:30.720] So, I think, you know, it's nice to extend the day.
[00:14:30.720 --> 00:14:36.960] I don't think that's wrong if you somehow can block that light from affecting your circadian clock.
[00:14:36.960 --> 00:14:40.400] You do keep your home quite dim to dark at night.
[00:14:40.400 --> 00:14:43.040] I am an extreme, but I measured it for myself.
[00:14:43.040 --> 00:14:45.600] And I asked Reiji, my wife, if she's okay with it.
[00:14:45.600 --> 00:14:46.880] She also liked the dimness.
[00:14:46.880 --> 00:14:49.840] Both of us can see well in dim conditions.
[00:14:49.840 --> 00:14:52.000] But I think you have to measure it for yourself.
[00:14:52.000 --> 00:14:54.080] You really have to do it.
[00:14:54.080 --> 00:14:55.680] It's a very simple experiment.
[00:14:55.680 --> 00:14:58.240] Just try to dim the light as much as you can.
[00:14:58.480 --> 00:15:03.280] I call it the minimum amount of light you require to see comfortably.
[00:15:03.280 --> 00:15:08.480] You know, use red light that is very dim if you want to keep the room for sleeping.
[00:15:08.800 --> 00:15:15.200] Red light that is very dim has very small effect on circadian clock.
[00:15:15.200 --> 00:15:19.440] And below 10 lux of red light literally doesn't affect sleep at all.
[00:15:19.440 --> 00:15:21.360] So there are ways to do it.
[00:15:21.360 --> 00:15:25.760] I've seen you check your phone after dark once or twice.
[00:15:26.160 --> 00:15:30.640] And you did it by sort of pointing your phone away from you, right?
[00:15:30.640 --> 00:15:34.320] It actually makes sense that, you know, if you shine a flashlight in your eye, it's much brighter than if you're lighter.
[00:15:34.560 --> 00:15:36.160] Light can only go in direct line.
[00:15:36.240 --> 00:15:40.480] So if you just look on the side, most of the light is going to go this way and you're only seeing this.
[00:15:41.040 --> 00:15:44.720] And even when I check, sometimes I check it so fast and switch it off so fast.
[00:15:44.720 --> 00:15:47.840] So ideally, I should not check iPhones and iPads.
[00:15:47.840 --> 00:15:53.040] I don't use iPad at night because it's hard to lower it enough because it's a huge.
[00:15:53.040 --> 00:15:56.240] But even my iPhone, I try not to use it at night.
[00:15:56.240 --> 00:16:16.840] You had what I consider absolutely landmark, beautiful paper published in Nature a few years ago, showing that if you disrupt the exposure to light or the timing of the exposure to light, that there are dramatic effects on the stress system and on the learning and memory system.
[00:16:16.840 --> 00:16:31.000] So, if I interpret that correctly, that could mean that when we view light and how much light could make us feel happier or less happy or even depressed, stressed, learning, et cetera.
[00:16:31.320 --> 00:16:31.960] Bingo.
[00:16:32.280 --> 00:16:35.800] Even if we're sleeping and waking up at the appropriate time.
[00:16:35.800 --> 00:16:36.440] Bingo.
[00:16:36.440 --> 00:16:44.680] I mean, eventually, because we're talking about the whole system, eventually when you start having the other problems, you also develop sleep problems.
[00:16:44.680 --> 00:16:46.120] But you're absolutely right.
[00:16:46.120 --> 00:16:55.000] And in fact, now, research from Diego Fernandez in the lab have found that now we know that they actually require different brain regions.
[00:16:55.000 --> 00:17:01.160] So we don't only have a theory, we don't only have a light environment that showed they can be dissociated.
[00:17:01.160 --> 00:17:04.120] We know that they use completely different brain regions.
[00:17:04.120 --> 00:17:19.000] So the SCN that I told you about earlier, the place where the central pacemaker is, the one that receives direct input from the retina through the IPRGCs to adjust your circadian clock, is not the area that receives the light input for mood regulation.
[00:17:19.000 --> 00:17:20.920] It's a completely different brain region.
[00:17:20.920 --> 00:17:38.920] And what's really amazing, this region also receives direct input from the IPRGCs, but projects to areas in the brain that are known to regulate mood, including the ventral, medial, prefrontal, prefrontal cortex, which has been studied for many years to be impacted in a human depression.
[00:17:38.920 --> 00:18:01.120] So, just by this amazing serendipity to find that a region that is so deep in the advanced brain, like the prefrontal cortex is your executive brain, one of the most elaborated in humans, to see that they receive input from these ancient photoreceptors was stunning to us.
[00:18:01.120 --> 00:18:06.800] How does that find inform daily protocols for you or for other people?
[00:18:06.800 --> 00:18:15.360] So, that's why we came up with the tripartite model, because as a circadian biologist, I only thought of light through the circadian clock affecting behavior.
[00:18:15.360 --> 00:18:21.040] As a sleep biologist, they only thought of the homeostatic drive affecting sleep, affecting behavior.
[00:18:21.040 --> 00:18:26.160] And for people who study light for vision and other functions, they thought only of the environmental input.
[00:18:26.160 --> 00:18:33.440] But now, if you put them all together, you get with this tripartite model where it's really mind-boggling and it makes so much sense.
[00:18:33.440 --> 00:18:43.120] The organism doesn't want to depend on a single component, but if you could incorporate these three together, you could have a beautiful system that is well adapted.
[00:18:43.120 --> 00:18:45.440] So, let me tell you the sleep-wake cycle, right?
[00:18:45.440 --> 00:18:48.800] So, we know there is a homeostatic drive to affect sleep.
[00:18:48.800 --> 00:18:51.040] We've had beautiful talks about that.
[00:18:51.040 --> 00:18:53.520] Which is basically the longer you're awake, the more you want to be asleep.
[00:18:53.600 --> 00:18:55.440] So, that's your homeostatic drive.
[00:18:55.440 --> 00:19:03.200] We've talked about the circadian influence of sleep and the fact that light-dark cycles affect the circadian system, which eventually affects sleep.
[00:19:03.200 --> 00:19:05.360] So, these two components are well understood.
[00:19:05.360 --> 00:19:09.280] Now, the third factor is your direct light or environmental input.
[00:19:09.280 --> 00:19:14.000] How much stress, how much light you get from there also can highly impact sleep.
[00:19:14.000 --> 00:19:24.160] So, even if you have a good circadian and homeostatic drive, if you're getting light at the wrong time of the day, or if you're being stressed and thinking, then your sleep is going to suffer.
[00:19:24.160 --> 00:19:29.800] So, you have to think of the three together to have a beautiful sleep-wake cycle.
[00:19:29.800 --> 00:19:33.720] Let's talk about food and eating and appetite.
[00:19:29.440 --> 00:19:35.560] You had yet another.
[00:19:37.160 --> 00:19:40.840] Yes, I greatly admire your success in this way.
[00:19:40.840 --> 00:19:50.280] Yet another incredible discovery showing that there are direct effects of light on appetite and feeding behavior.
[00:19:50.280 --> 00:20:00.120] So for somebody who's interested in affecting their eating behavior, how should they use light in order to adjust their eating behavior?
[00:20:00.120 --> 00:20:00.760] Right.
[00:20:00.760 --> 00:20:09.160] So now that I've told you about all these interactions between the different inputs to the circadian clock, just you think about it as an engineer.
[00:20:09.160 --> 00:20:10.600] What would be the best thing?
[00:20:10.600 --> 00:20:20.920] The best thing is to know when your food times happen in the day, when you should get light, and where is your circadian, when is your circadian clock in your system, right?
[00:20:21.560 --> 00:20:29.880] So if you eat at very specific times of the day, that's another signal that is telling your body, your clock, you're in a certain time of the day.
[00:20:29.880 --> 00:20:37.400] So if you're having lunch at the correct time every day and you're getting bright light, now you have two systems that are informing your clock.
[00:20:37.400 --> 00:20:38.920] Your clock is going to be better.
[00:20:38.920 --> 00:20:40.360] So regular meal times.
[00:20:40.360 --> 00:20:43.560] Regular meantimes that fit your circadian clock.
[00:20:43.560 --> 00:20:53.400] So, and in fact, if you do that, when I started doing this and it helped me lose weight, is that I'm exposing myself to the right amount of light, dark cycle.
[00:20:53.400 --> 00:20:55.240] I'm eating at regular time.
[00:20:55.240 --> 00:20:56.360] It is amazing.
[00:20:56.360 --> 00:20:57.480] You will be not hungry.
[00:20:57.480 --> 00:20:59.080] Let's say, let's say you eat at noon.
[00:20:59.080 --> 00:21:01.960] You will not feel any hunger at 11:45.
[00:21:01.960 --> 00:21:04.600] And then all of a sudden, the hunger jumps in.
[00:21:04.600 --> 00:21:08.680] This is clearly not an energy issue because it could not be that drastic.
[00:21:08.680 --> 00:21:08.840] Right.
[00:21:08.840 --> 00:21:21.520] No, the desire to eat is mainly driven by these cues, these hormone cues that are very exquisitely timed to sleep-wake cycle, but also to light.
[00:21:21.760 --> 00:21:22.560] Exactly.
[00:21:22.560 --> 00:21:27.200] How regular are you, or do you recommend people be about meal times?
[00:21:27.200 --> 00:21:28.880] Are we talking about down to the minute?
[00:21:28.880 --> 00:21:37.280] Like, if I absolutely, all right, plus or so, 12:00 is my normal lunch, let's say, uh, plus or minus half an hour.
[00:21:37.280 --> 00:21:40.880] Okay, yeah, so eat around between 11:30 and 12:30.
[00:21:40.880 --> 00:21:44.640] If that's the time, and it depends if you also do multiple meals.
[00:21:44.640 --> 00:21:48.480] Remember, three meals-that's a decision that somebody came up with.
[00:21:48.480 --> 00:21:49.280] I don't know why.
[00:21:49.280 --> 00:21:51.440] Nowadays, people are fewer people are doing that, I think.
[00:21:51.440 --> 00:21:54.400] Yeah, given our friends such in Panda's work, right?
[00:21:54.400 --> 00:22:02.880] I mean, so you could have two meals, you could have very multiple meals that are distributed across your active time.
[00:22:02.880 --> 00:22:11.520] Some people are not hungry early in the day, they might be late-shifted people, in which case, eating later in the day will work well for them as long as they don't eat early in the morning.
[00:22:11.520 --> 00:22:15.520] That's just you have to work with your schedule, with your active schedule.
[00:22:15.520 --> 00:22:25.360] What we're talking about really is finding your ideal sleep schedule and finding your ideal eating schedule and understanding how those two things interact.
[00:22:25.360 --> 00:22:38.480] And you know, the nice thing, as you said, finding them out is going to help you to understand how they interact because we know from the tripartite model that they are all interconnected, and for each person, they're going to be interconnected differently.
[00:22:38.480 --> 00:22:53.760] It's striking to me that in all animals, besides humans, if they deviate too much from the appropriate exposure to light and light-dark cycle, they essentially don't mate and/or die and/or get killed off.
[00:22:53.760 --> 00:22:58.160] But in humans, we are able to override that at least to some extent.
[00:22:58.160 --> 00:23:12.680] But the ways in which we suffer appear to be things like obesity, metabolic syndromes, reproductive syndromes that accompany the other syndromes, you know, endocrine syndromes, and mood and depressive disorders.
[00:23:12.680 --> 00:23:23.960] Is there any effort at the level of the nationally or laboratories that you're aware of to try and use light in order to improve mood and mental health?
[00:23:23.960 --> 00:23:26.120] I mean, honestly, this is my moonshot.
[00:23:26.120 --> 00:23:32.360] This is the thing that I think people, because it's, I say, don't take a pill, take a photon.
[00:23:32.360 --> 00:23:34.600] And not, I mean, you take pills, it's important.
[00:23:34.600 --> 00:23:57.240] I'm just making it that really we have an opportunity right now with the incredible advances of LED lights, of changing spectra of light, of regulating intensities, and just to associate, just for simple changes, you could really improve sleep-wake cycle, productivity, and still, you could actually get more done.
[00:23:57.240 --> 00:24:06.440] Because, as we've talked about, when you have all these messed up, now you have to sleep more, but your sleep is fragmented, it's not very good, and you can't focus.
[00:24:06.680 --> 00:24:10.920] And you can't focus when you don't have alertness when you need the alertness.
[00:24:10.920 --> 00:24:16.760] So, having all these could allow you to do even more actually at the end than less.
[00:24:16.760 --> 00:24:19.480] And that's the exciting part of it.
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[00:25:42.480 --> 00:25:44.880] Let's talk about jet lag.
[00:25:45.120 --> 00:25:50.080] What are the two or three things that people can do to adjust their schedule quickly?
[00:25:50.080 --> 00:25:55.280] Like, let's say fall classes are starting, you start a new job, or you have a baby or a puppy or whatever.
[00:25:55.280 --> 00:25:58.000] What is the best way to shift the clock quickly?
[00:25:58.000 --> 00:26:00.400] So, it's very simple, as we've talked yesterday.
[00:26:00.400 --> 00:26:06.480] So, imagine you're in the outside with no environmental, with no industrial light.
[00:26:07.280 --> 00:26:12.720] If your body thinks you're in early evening and you see a bright light, what does this tell you?
[00:26:12.720 --> 00:26:15.440] Oh, wait, this is not early evening yet.
[00:26:15.440 --> 00:26:18.880] It's still early afternoon or late afternoon.
[00:26:18.840 --> 00:26:22.880] So, so I have to delay my clock to go back to late afternoon.
[00:26:22.880 --> 00:26:27.680] So, if you get light early in the evening, it delays your clock.
[00:26:27.680 --> 00:26:30.000] So, what does that make you want to go to sleep later?
[00:26:30.600 --> 00:26:31.880] Yes, it delays your clock.
[00:26:31.880 --> 00:26:43.480] So later in the night, later in your night, and actually, it just happens that in humans, you get a temperature in the deer later in the night, low temperature in your body.
[00:26:43.480 --> 00:26:46.760] After that, lights start advancing your clock.
[00:26:46.760 --> 00:26:57.800] If I understand correctly, what you're saying is if your typical wake-up time is, say, 7 a.m., then your low point in temperature probably occurs somewhere around 5 a.m.
[00:26:58.600 --> 00:27:03.800] And if you view light right around then, it's going to essentially advance your clock.
[00:27:03.800 --> 00:27:09.320] Yeah, because then your body thinks, oh, it's seven o'clock, so advance your clock by one to two hours.
[00:27:09.320 --> 00:27:15.080] But if I were to view light, say at 3 a.m., then it would probably delay my clock.
[00:27:15.080 --> 00:27:15.480] Yeah.
[00:27:15.480 --> 00:27:16.120] Okay.
[00:27:16.120 --> 00:27:16.520] Yeah.
[00:27:16.680 --> 00:27:19.400] So, and then let's say I land in a new schedule.
[00:27:19.560 --> 00:27:20.680] I want to adjust to a new schedule.
[00:27:20.680 --> 00:27:25.800] Let's say I didn't manage to do anything with my light viewing before I went and I didn't do it, I didn't anticipate the trip.
[00:27:25.800 --> 00:27:27.560] Suddenly, I'm on a new schedule.
[00:27:27.560 --> 00:27:28.120] Okay.
[00:27:28.440 --> 00:27:44.440] I was told that one of the ways to help shift the clock and to avoid gastrointestinal issues is to eat on the local schedule to start basically behaving like a local, even though your circadian clock will take a little bit of time to catch up.
[00:27:44.440 --> 00:27:45.240] Absolutely.
[00:27:45.240 --> 00:27:47.640] But you have to remember the light, right?
[00:27:47.640 --> 00:27:52.760] So let's now that we explained it very simply, let's take a very simple example, right?
[00:27:53.080 --> 00:27:54.440] New York to Italy.
[00:27:54.440 --> 00:27:56.120] That's a simple example.
[00:27:56.120 --> 00:27:59.080] New York time, Italy time, six-hour difference, right?
[00:27:59.080 --> 00:28:04.280] So let's say you fly from New York at night, you reach Italy at eight o'clock in the morning.
[00:28:04.280 --> 00:28:06.760] What is the time in your New York time?
[00:28:07.080 --> 00:28:10.520] Although you reach six hours back, six hours back, it's 2 a.m.
[00:28:10.760 --> 00:28:14.440] So when you land Italy, you want to avoid light like the plague.
[00:28:14.440 --> 00:28:17.200] Yeah, you could eat, but you really don't want to get alive.
[00:28:17.200 --> 00:28:18.480] Right, because otherwise it's going to delay you.
[00:28:18.720 --> 00:28:22.080] That delay is going to send you to California instead of sending you to Italy.
[00:28:14.840 --> 00:28:22.160] Right.
[00:28:22.240 --> 00:28:24.640] What Sam was saying is so crucial.
[00:28:24.960 --> 00:28:34.720] Just because getting bright light in your eyes early in the day is really beneficial when you're at home, when you travel to a new time zone, you have to take into account where your body thinks you are.
[00:28:34.720 --> 00:28:43.440] And so if you're looking at the Italian sunrise, having just flown from New York to Italy, and you didn't prepare for that trip by waking up a little bit earlier in anticipation, multiple days.
[00:28:43.600 --> 00:28:45.200] And you view light at 2 a.
[00:28:45.360 --> 00:28:47.680] excuse me, at 6 or 7 a.m.
[00:28:47.920 --> 00:28:52.320] Italian time, beautiful Italian sunrise, you are going to delay your clock.
[00:28:52.320 --> 00:28:56.320] You're going to basically throw yourself back to California, but you are in Italy.
[00:28:56.320 --> 00:29:03.440] You're going to throw your biology back to California and you are going to be up in the middle of the Italian night and you're going to be miserable.
[00:29:03.760 --> 00:29:13.600] It's very important to avoid getting the wrong light information when you're trying to adjust your body because otherwise it shifts you to the other cycle.
[00:29:13.600 --> 00:29:14.720] Absolutely, right?
[00:29:15.040 --> 00:29:17.760] You are one of these people that has such vigor.
[00:29:17.760 --> 00:29:33.520] I think a lot of your ability to work hard and focus and really do so many things at an impressive level is because you think about these issues and you think about when you're going to be optimal for focus, when you're going to be optimal for exercise, when, and the when is the key.
[00:29:34.080 --> 00:29:38.960] And I think a lot of people live in the landscape of feeling like there's something broken inside them.
[00:29:38.960 --> 00:29:49.200] I really agree with you that I think part of the reason I'm continuing to be able to do this, that I really think about it and I make sure that I keep everything aligned.
[00:29:49.200 --> 00:29:51.360] And that actually helps me a lot.
[00:29:51.360 --> 00:29:53.600] Like, I don't suffer in sleep.
[00:29:53.600 --> 00:29:54.960] I don't suffer in waking up.
[00:29:54.960 --> 00:29:57.040] I never use a timer to wake up.
[00:29:57.200 --> 00:29:58.960] System is so aligned.
[00:29:58.960 --> 00:30:00.040] It works.
[00:29:59.520 --> 00:30:06.600] A lot of times, people will say, How come I go to sleep, I fall asleep fine, but then I wake up at three or four in the morning and can't fall back asleep.
[00:30:07.080 --> 00:30:10.520] Is it possible that those people were supposed to go to bed at 8 p.m.?
[00:30:10.520 --> 00:30:21.240] Yeah, I mean, it is possible, or it's possible that their clock is completely misaligned, that they are getting maybe enough time at night when they are supposed, and then they possibly feel so sleepy in the day.
[00:30:21.240 --> 00:30:23.560] So, there, all these are possible combinations.
[00:30:23.560 --> 00:30:24.520] Well, that's an interesting idea.
[00:30:24.520 --> 00:30:31.480] I hadn't considered so that what they think is their sleep, their body is so out of whack with the light-dark cycle that it's actually a nap.
[00:30:31.480 --> 00:30:33.880] A nap or the weaker part of the sleep.
[00:30:33.880 --> 00:30:39.000] I mean, you see this in when you travel to different time zone before you adjust.
[00:30:39.000 --> 00:30:43.080] You go to sleep really well, but two hours later, you're fully up.
[00:30:43.080 --> 00:30:44.120] Two hours.
[00:30:44.120 --> 00:30:49.720] If you were so tired and this is your regular sleep, there's no way you're gonna wake up in two hours.
[00:30:49.720 --> 00:30:52.200] Let's talk about seasonality a little bit.
[00:30:52.200 --> 00:30:56.120] Are there other effects of seasonality on humans that we are aware of?
[00:30:56.120 --> 00:31:00.120] Honestly, you could see it perfectly, I think, in Scandinavia.
[00:31:00.120 --> 00:31:04.920] I mean, you could talk to people who live in sure they get seasonal depression.
[00:31:04.920 --> 00:31:15.400] What seasonal depression is one, but actually, when you start asking them questions, they tell you like in the winter, they barely could wake up, they barely have the energy before even depression.
[00:31:15.400 --> 00:31:23.080] Even people who don't get seasonal depression, they'll tell you our energy level is lower, our ability to go to work is not the same.
[00:31:23.080 --> 00:31:26.760] And in the summer, most people actually sleep very little.
[00:31:26.760 --> 00:31:35.480] They tell you we really can feel like we're manic, we have all this energy, and not in a negative way, in a funny way, right?
[00:31:35.480 --> 00:31:38.840] I mean, but if you want to sleep, we have to put this curtain.
[00:31:38.840 --> 00:31:44.280] I think in these situations, you could really appreciate the seasonality of humans.
[00:31:44.520 --> 00:31:51.600] I think we kind of destroyed our seasonality because we don't get exposed to that much natural light.
[00:31:51.600 --> 00:31:53.280] We have all this artificial light.
[00:31:53.280 --> 00:32:06.640] But I think, honestly, one of the things that is going to happen if they follow your recommendation, this is going to cause them to also experience some changes across the season because now they're going to see the sun differently.
[00:32:06.640 --> 00:32:11.200] If you're going to go out in the morning in the summer, you're going to get a much brighter time.
[00:32:11.200 --> 00:32:12.960] That's why I don't like the change in time.
[00:32:12.960 --> 00:32:15.680] I know people think, oh, because you're biased.
[00:32:16.160 --> 00:32:19.920] Because I think sorry, the change in are you talking about daylight savings?
[00:32:19.920 --> 00:32:20.720] Daylight saving.
[00:32:20.720 --> 00:32:25.760] It's such a bad idea because it disrupts that rhythm that you're having.
[00:32:25.760 --> 00:32:30.480] Because I think your body, if you keep that rhythm, you will see the whole seasonality.
[00:32:30.480 --> 00:32:33.840] And I look at it from a different aspect than other people.
[00:32:33.840 --> 00:32:48.800] If you think about it, Andrew, there is a situation where you're getting light perfectly well, and then all of a sudden they delay it by one hour because, and then even though it's the summer, your body now, if you're still not adjusting, think, oh, wait, what happened?
[00:32:48.800 --> 00:32:49.840] What kind of happened?
[00:32:49.840 --> 00:32:54.480] Well, I'm glad you're bringing this up because I always thought, you know, what's the big deal?
[00:32:54.480 --> 00:32:55.520] One hour, right?
[00:32:55.520 --> 00:32:57.520] One hour shift, you know, spring forward fallback.
[00:32:57.760 --> 00:32:59.440] Adjust one hour actually.
[00:32:59.440 --> 00:33:03.040] But the, but this goes back to the beginning of our discussion.
[00:33:03.040 --> 00:33:04.640] It's not just one hour.
[00:33:04.640 --> 00:33:05.120] Right.
[00:33:05.120 --> 00:33:14.080] Because it's one hour across that one day, but there's this cumulative effect on the clock and these three elements of your tripartite model, right?
[00:33:14.160 --> 00:33:17.360] The homeostatic sleep and the light direct effects on mood.
[00:33:17.360 --> 00:33:26.000] And when it's so close, it's sometimes hard to figure out how to adjust it perfectly because, you know, we're already sleep-deprived in our society.
[00:33:26.000 --> 00:33:32.200] And then you shift it by, you know, so it just, it all accumulates and it has no benefit.
[00:33:32.200 --> 00:33:34.200] I just don't understand why they do this.
[00:33:29.840 --> 00:33:35.160] It makes no sense.
[00:33:35.480 --> 00:33:40.440] Well, I think that the reason they do it is because they don't understand the biology.
[00:33:40.440 --> 00:33:46.680] Because one hour seems trivial unless you understand the repercussions of that one-hour shift.
[00:33:46.680 --> 00:33:57.000] Because what's also clear now, based on what you're saying, is that that one-hour shift is taking you out of alignment with the natural light-dark cycle in exactly the wrong direction.
[00:33:57.000 --> 00:34:03.080] It's pushing people to get even later in the summer when light is going to push you later anyway.
[00:34:03.080 --> 00:34:07.000] It's really compounding the problem that already exists.
[00:34:07.000 --> 00:34:13.160] Samer, this has been an amazing march through the importance of light.
[00:34:13.160 --> 00:34:23.720] I'm certain that people are going to start thinking about how to change their relationship with light as a way to anchor everything that they do and that's important to their health.
[00:34:23.720 --> 00:34:25.640] Let's talk a little bit about where people can find you.
[00:34:25.640 --> 00:34:28.280] Your laboratory is at the National Institutes of Mental Health.
[00:34:28.280 --> 00:34:32.200] He is head of the chronobiology unit, all these things that I've mentioned earlier.
[00:34:32.200 --> 00:34:35.560] But you are active on Twitter and Instagram.
[00:34:35.560 --> 00:34:35.880] Right.
[00:34:35.880 --> 00:34:37.960] So, what is your Twitter handle?
[00:34:37.960 --> 00:34:39.640] It's at Samur Hattar.
[00:34:39.640 --> 00:34:41.320] And I think the same for Instagram.
[00:34:41.320 --> 00:34:44.440] So, definitely give him a follow there and on Twitter.
[00:34:44.440 --> 00:34:54.120] And I'm sure that he'll be happy to answer questions and entertain any and all discussions about chronobiology.
[00:34:54.120 --> 00:34:54.760] Absolutely.
[00:34:54.760 --> 00:34:55.160] Yeah.
[00:34:55.160 --> 00:34:56.360] And light.
[00:34:56.360 --> 00:34:56.840] Yeah.
[00:34:57.400 --> 00:34:57.720] Great.
[00:34:57.720 --> 00:34:58.680] Thank you, Samer.
[00:34:58.680 --> 00:34:59.000] Awesome.
[00:34:59.000 --> 00:35:00.360] Thank you, Rank.

Prompt 2: Key Takeaways

Now please extract the key takeaways from the transcript content I provided.

Extract the most important key takeaways from this part of the conversation. Use a single sentence statement (the key takeaway) rather than milquetoast descriptions like "the hosts discuss...". 

Limit the key takeaways to a maximum of 3. The key takeaways should be insightful and knowledge-additive. 

IMPORTANT: Return ONLY valid JSON, no explanations or markdown. Ensure:
- All strings are properly quoted and escaped
- No trailing commas
- All braces and brackets are balanced
Format: {"key_takeaways": ["takeaway 1", "takeaway 2"]}

Prompt 3: Segments

Now identify 2-4 distinct topical segments from this part of the conversation.

For each segment, identify:
- Descriptive title (3-6 words)  
- START timestamp when this topic begins (HH:MM:SS format)
- Double check that the timestamp is accurate - a timestamp will NEVER be greater than the total length of the audio
- Most important Key takeaway from that segment. Key takeaway must be specific and knowledge-additive.
- Brief summary of the discussion

IMPORTANT: The timestamp should mark when the topic/segment STARTS, not a range. Look for topic transitions and conversation shifts.

Return ONLY valid JSON. Ensure all strings are properly quoted, no trailing commas:
{
  "segments": [
    {
      "segment_title": "Topic Discussion", 
      "timestamp": "01:15:30",
      "key_takeaway": "main point from this segment",
      "segment_summary": "brief description of what was discussed"
    }
  ]
}

Timestamp format: HH:MM:SS (e.g., 00:05:30, 01:22:45) marking the START of each segment.

Prompt 4: Media Mentions

Now scan the transcript content I provided for ACTUAL mentions of specific media titles:

Find explicit mentions of:
- Books (with specific titles)
- Movies (with specific titles)  
- TV Shows (with specific titles)
- Music/Songs (with specific titles)

DO NOT include:
- Websites, URLs, or web services
- Other podcasts or podcast names

IMPORTANT: 
- Only include items explicitly mentioned by name. Do not invent titles.
- Valid categories are: "Book", "Movie", "TV Show", "Music"
- Include the exact phrase where each item was mentioned
- Find the nearest proximate timestamp where it appears in the conversation
- THE TIMESTAMP OF THE MEDIA MENTION IS IMPORTANT - DO NOT INVENT TIMESTAMPS AND DO NOT MISATTRIBUTE TIMESTAMPS
- Double check that the timestamp is accurate - a timestamp will NEVER be greater than the total length of the audio
- Timestamps are given as ranges, e.g. 01:13:42.520 --> 01:13:46.720. Use the EARLIER of the 2 timestamps in the range.

Return ONLY valid JSON. Ensure all strings are properly quoted and escaped, no trailing commas:
{
  "media_mentions": [
    {
      "title": "Exact Title as Mentioned",
      "category": "Book",
      "author_artist": "N/A",
      "context": "Brief context of why it was mentioned",
      "context_phrase": "The exact sentence or phrase where it was mentioned",
      "timestamp": "estimated time like 01:15:30"
    }
  ]
}

If no media is mentioned, return: {"media_mentions": []}

Full Transcript

[00:00:00.160 --> 00:00:11.040] Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance.
[00:00:12.000 --> 00:00:18.080] I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
[00:00:18.080 --> 00:00:20.240] Today, I have the pleasure of introducing Dr.
[00:00:20.240 --> 00:00:23.920] Samer Hattar as my guest on the Huberman Lab podcast.
[00:00:23.920 --> 00:00:25.840] And now, my conversation with Dr.
[00:00:25.840 --> 00:00:27.440] Samer Hattar.
[00:00:27.440 --> 00:00:30.240] Samer, thanks for sitting down with me.
[00:00:30.240 --> 00:00:31.040] My pleasure.
[00:00:31.040 --> 00:00:41.520] You are best known in scientific circles for your work on how light impacts mood, learning, feeding, hunger, sleep, and these sorts of topics.
[00:00:41.520 --> 00:00:49.520] So maybe you could just weigh us into what the relationship is between light and these things like mood and hunger, etc.
[00:00:49.760 --> 00:00:50.400] Sure.
[00:00:50.720 --> 00:00:54.800] So, I mean, you do appreciate the effect of light for vision.
[00:00:54.800 --> 00:01:00.800] So, when you wake up in a beautiful area, beautiful ocean, light is essential.
[00:01:00.800 --> 00:01:02.960] The sunrise, the sunset.
[00:01:02.960 --> 00:01:05.920] So, that's your conscious perception of light.
[00:01:05.920 --> 00:01:11.360] But light has a completely different aspect that is independent of conscious vision.
[00:01:11.360 --> 00:01:15.600] And that's how it regulates many important functions in your body.
[00:01:15.600 --> 00:01:20.800] I think the best that is well studied and well-known is your circadian clock.
[00:01:20.800 --> 00:01:26.000] And the word circadian comes from the word circa, which is approximate, and DN is day.
[00:01:26.000 --> 00:01:27.440] So, it's an approximate day.
[00:01:27.440 --> 00:01:29.360] Why is it an approximate day?
[00:01:29.360 --> 00:01:45.760] Because if I put you or any other human being who have a normal circadian clock in a constant condition with no information about feeding time, about sleep time, about what time it is outside, you still have a daily rhythm, but it's not exactly 24 hours.
[00:01:45.760 --> 00:01:51.800] So, it will shift out of the solar day because it's not exactly 24 hours, and hence the name circadio.
[00:01:52.000 --> 00:01:54.880] How does that rhythm show up in the tissues of our body?
[00:01:54.880 --> 00:01:57.760] It shows up at every level that we know we studied.
[00:01:57.760 --> 00:02:03.640] It shows up at the level of the cell, it shows up at the level of the tissue, and it shows up at your behavior.
[00:01:59.600 --> 00:02:06.600] The most obvious for you is your sleep-wake cycle.
[00:02:06.920 --> 00:02:10.920] You sleep and you're awake and sleep at the 24-hour rhythms.
[00:02:10.920 --> 00:02:15.080] The period length of the sleep rhythm on average is 24.2 hours.
[00:02:15.080 --> 00:02:20.760] So you'll be drifting 0.2 hours every day out of the solar day if you don't get the sunlight.
[00:02:20.760 --> 00:02:25.720] So the sunlight adjusts that approximate day to an exact day.
[00:02:25.720 --> 00:02:31.160] So now your behavior is adjusted to the light-dark environment or the solar day.
[00:02:31.160 --> 00:02:34.440] It's part of the brain that is not consciously driven.
[00:02:34.440 --> 00:02:37.560] So you actually do not know when it happens or when it doesn't happen.
[00:02:37.560 --> 00:02:46.040] And that's what we'll get into when I tell you why light affects your mood and why sometimes people don't know how to deal with light to improve their mood, for example.
[00:02:46.040 --> 00:02:46.840] What's the relevance?
[00:02:46.840 --> 00:02:48.840] I mean, why should we care about that short difference?
[00:02:48.840 --> 00:02:49.960] So let's do the math.
[00:02:49.960 --> 00:02:54.040] If you shift out 0.2 hours a day in five days, you're shifting out one hour.
[00:02:54.040 --> 00:02:58.920] So you're literally one hour off in your social behavior in five days.
[00:02:58.920 --> 00:03:01.000] In 10 days, you're two hours off.
[00:03:01.000 --> 00:03:09.320] And if you're an organism that is living in the wild, shifting out of the right phase of the cycle, you could either miss food or you could become food.
[00:03:09.320 --> 00:03:11.560] So it's really essential for survival.
[00:03:11.560 --> 00:03:20.680] I think it's one of the strongest aspects of survival for animals to have the anticipation and the adjustment to the solar cycle.
[00:03:20.680 --> 00:03:25.320] What is the machinery that allows that to happen?
[00:03:25.320 --> 00:03:27.960] And how does that machinery work?
[00:03:27.960 --> 00:03:34.840] Yeah, so we knew that in mammals, including us, we are mammals, humans, that the eyes are required for this function.
[00:03:34.840 --> 00:03:43.000] So, if humans are born without eyes or the optic nerves are damaged, humans are not able to adjust to the solar cycle.
[00:03:43.000 --> 00:03:44.960] So, we know that the eyes are required.
[00:03:44.960 --> 00:03:48.800] In the human retinas, there are two types of photoreceptors.
[00:03:44.600 --> 00:03:51.600] They are called rods and cones because of their shapes.
[00:03:51.920 --> 00:04:04.400] And these rods and cones simply take the photon energy, which light is made of, and they change it in a way to an electrical signal that allows us to build the image of the environment in our cortices.
[00:04:04.400 --> 00:04:13.120] However, people have found, including me with the work of David Burson and Ignacio Provencio, that there is a subset of ganglion cells.
[00:04:13.120 --> 00:04:19.360] The ganglion cells are the cells that leave the retina, their axon, leave the retina, and project to the brain.
[00:04:19.360 --> 00:04:25.680] So, these were thought to only relay rod and cone information from the light environment to the brain.
[00:04:25.680 --> 00:04:33.600] We found that a small subset of these ganglion cells are themselves photoreceptors that were completely missed in the retina.
[00:04:33.600 --> 00:04:54.000] And these are the photoreceptors that relay light environment subconsciously to the areas in the brain that have and house the circadian clock or the circadian pacemaker, which adjusts all the clocks in our bodies to the central brain clock that allows them to entrain to the 24-hour light-dark cycle.
[00:04:54.000 --> 00:04:58.160] So, these are cells that connect the eye of the brain that behave like photoreceptors, essentially.
[00:04:58.160 --> 00:05:16.720] I think it's worth mentioning now that people who are pattern vision blind, so people who cannot see but have eyes, many of them still have these cells, these melanops and intrinsically photosensitive cells, and can essentially match or entrain, as we say, onto the light-dark cycle.
[00:05:16.720 --> 00:05:20.000] In fact, they possibly have no problems in circadian photo entrainment.
[00:05:20.000 --> 00:05:22.160] They'll have enormous sleep-wake cycle.
[00:05:22.160 --> 00:05:23.200] But they're totally blind.
[00:05:23.200 --> 00:05:24.800] But they are totally image-blind.
[00:05:24.800 --> 00:05:36.040] And what's really interesting is that, and this story I heard from Chuck Seisler, so I'll give him credit: that some of these people who are image blind usually they get dry eyes and they give them a lot of pain.
[00:05:36.360 --> 00:05:42.600] And doctors used to think, oh, since they are image blind and they're getting dry eye, why don't you just remove their eyes?
[00:05:42.600 --> 00:05:44.200] They're not using them anymore.
[00:05:44.200 --> 00:05:58.440] And the minute they would remove their eyes, they start having cyclical sleep problems, indicating that now they are not in training to the light-dark cycle and are having cyclical jet lags when their clock shifts through the light-dark cycle.
[00:05:58.440 --> 00:05:59.560] That's really interesting.
[00:05:59.560 --> 00:06:12.760] And I hear from a number of blind people, a lot of them have issues with sleep, I think, in part because they don't realize that they too need to see light at particular times of day or night in order to absolutely.
[00:06:12.760 --> 00:06:18.600] What is the proper way to interact with light in the first part of the day?
[00:06:18.600 --> 00:06:20.920] Honestly, I think the easiest thing is waking up.
[00:06:20.920 --> 00:06:22.280] Get as much light as you can.
[00:06:22.360 --> 00:06:23.160] To your eyes.
[00:06:23.160 --> 00:06:24.360] Yeah, it's really nice.
[00:06:24.360 --> 00:06:25.720] Your system is primed.
[00:06:25.720 --> 00:06:27.800] If you're entrained, it's primed to get light.
[00:06:27.800 --> 00:06:29.240] The sun should be out.
[00:06:29.240 --> 00:06:34.760] Even when it's cloudy, you're going to get enough intensity to help you adjust your cycle to the day-night cycle.
[00:06:34.760 --> 00:06:37.800] These are general rules of thumb, but how long do you recommend people go out?
[00:06:38.120 --> 00:06:40.600] If you do it daily, I would say 15 minutes.
[00:06:40.600 --> 00:06:42.920] If you don't do it daily, you may want to increase it.
[00:06:42.920 --> 00:06:44.600] You do it more, it doesn't hurt.
[00:06:44.600 --> 00:06:48.520] And I'll tell you, if you're sensitive, you don't even have to go in the sun.
[00:06:48.520 --> 00:06:49.800] You could be in the shade.
[00:06:49.800 --> 00:06:52.920] There's going to be so many photons out there in the shade.
[00:06:52.920 --> 00:06:54.280] It's going to be perfect.
[00:06:54.280 --> 00:06:54.520] Okay.
[00:06:54.520 --> 00:07:09.800] And if for some reason one finds themselves very far north and it's very, very dense cloud cover, how long and at what point should somebody consider using an artificial light source to mimic the sunlight?
[00:07:09.800 --> 00:07:17.680] Yeah, honestly, this is where we don't have a lot of information still, because this is where we're going to discuss this maybe in more detail.
[00:07:17.840 --> 00:07:24.960] That if you put humans in artificial conditions, the circadian system is very sensitive to light.
[00:07:25.280 --> 00:07:34.960] But in reality, in the real environment, light also is affecting other aspects that are independent of the setting of the circadian base maker.
[00:07:34.960 --> 00:07:35.280] Okay.
[00:07:35.280 --> 00:07:39.520] And these, which we call the direct effect of light on mood, for example.
[00:07:39.520 --> 00:07:43.360] So that is very hard to figure out what intensity you need to use.
[00:07:43.360 --> 00:07:47.840] And we haven't done enough experiments because the system has been discovered just recently.
[00:07:47.840 --> 00:07:57.440] But yeah, I mean, if you're honestly, if you're that far north and you're in the winter and you want to make sure you don't use these light boxes, I would suggest that personally.
[00:07:57.440 --> 00:08:01.120] Okay, so I think we've nailed down that first part of the day.
[00:08:01.120 --> 00:08:08.720] Basically, it's get 10 to 30 minutes, depending on how bright it is, and try and do that as often as possible to give the system a regular daily is the best.
[00:08:08.720 --> 00:08:15.040] This system is really about, and you'll see that even for the effect on depression, it's about multiple days.
[00:08:15.680 --> 00:08:20.320] So you don't have to worry if you missed it one day, you know, stay longer if you want.
[00:08:20.320 --> 00:08:24.560] But if you're in a hurry and you want to do other stuff, that's a great recommendation.
[00:08:24.560 --> 00:08:27.680] So you might want to compensate with some extra time if you missed a day or two.
[00:08:27.680 --> 00:08:32.800] I've heard you say before it's entirely possible to get severely jet lagged without traveling.
[00:08:32.800 --> 00:08:33.600] Absolutely.
[00:08:33.600 --> 00:08:36.960] Simply by staying in, being on your phone too much, not getting the sunlight.
[00:08:36.960 --> 00:08:38.880] And you saw this during the pandemic.
[00:08:38.880 --> 00:08:43.280] A lot of people mentioned that their sleep-wake cycles suffered a lot.
[00:08:43.600 --> 00:08:56.080] Because if you're not going out and if you're staying at home and you don't have big windows and you're waking late, waking up late, and then you're using very bright light till late at night, your body is going to shift.
[00:08:56.080 --> 00:09:04.760] And now, your day is going to start instead of like really when the sun comes up, let's say at six o'clock in the morning, it's gonna your day is gonna start at 11 o'clock in the morning.
[00:09:04.920 --> 00:09:08.360] That's what your body's gonna think is the beginning of the day.
[00:09:08.680 --> 00:09:18.120] So, then you're not gonna be able to sleep at 10 o'clock at night because now that's really for your body is completely different timing.
[00:09:18.120 --> 00:09:21.640] I'd like to take a quick break and acknowledge our sponsor, 8-Sleep.
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[00:10:59.440 --> 00:11:02.080] Today's episode is also brought to us by ROCA.
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[00:11:11.280 --> 00:11:17.840] They filter out short wavelength light that comes from screens and from LED lights, which are the most common indoor lighting nowadays.
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[00:11:30.800 --> 00:11:33.600] By the way, you want melatonin high in the evening and at night.
[00:11:33.600 --> 00:11:35.920] It makes it easy to fall and stay asleep.
[00:11:35.920 --> 00:11:39.600] And those short wavelengths trigger increases in cortisol.
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[00:12:14.240 --> 00:12:29.760] There is this idea of chronotypes that we all each intrinsically have a best rhythm of either being a morning person, you called yourself an early person, or a night owl, or more of a kind of standard, you know, to bed around 10:30, up around 7 type thing.
[00:12:29.960 --> 00:12:44.200] And the and I think there are now good data, correct me if I'm wrong, from the National Institutes of Mental Health and elsewhere showing that the more we deviate from that intrinsic rhythm, the more mental health issues and physical health issues start to crop up.
[00:12:44.200 --> 00:12:48.120] So, there is great data on this, and there's a couple of things that complicate this.
[00:12:48.120 --> 00:12:51.400] The first is the people who usually are late.
[00:12:51.400 --> 00:12:53.160] What do you mean, people that wake up late and go to sleep?
[00:12:53.400 --> 00:13:04.120] Go to sleep late and wake up late, they have an overwhelmingly higher level of depression because human notice that people who go to sleep early and wake up early, they do better in life.
[00:13:04.120 --> 00:13:05.960] They notice that they just perform better.
[00:13:05.960 --> 00:13:11.080] They perform, but the question is: is that intrinsic to the system or is that society?
[00:13:11.080 --> 00:13:13.720] Because society starts things usually early or late.
[00:13:13.720 --> 00:13:14.680] That's a hard question.
[00:13:14.680 --> 00:13:16.360] We discriminate against late rises.
[00:13:16.680 --> 00:13:18.120] In a way, we discriminate.
[00:13:18.120 --> 00:13:22.600] And I'm not so sure that the circadian system is that variable in the human population.
[00:13:22.600 --> 00:13:29.880] I mean, clearly, there are maybe some genetic factors that make a small percentage of like everything with a bell shape.
[00:13:29.880 --> 00:13:33.640] But I think most of the time the light environment may play a role.
[00:13:33.640 --> 00:13:38.280] And once, as you, as we've talked about, this is a long-term effect of light.
[00:13:38.280 --> 00:13:47.800] Once you get into a rhythm, it's hard to break out of that rhythm because if you start sleeping late and waking up late, you're not getting the morning sunlight.
[00:13:47.800 --> 00:13:48.200] Right.
[00:13:48.440 --> 00:13:50.680] And so, you're just going to be late.
[00:13:50.680 --> 00:14:05.960] It seems to me the case is that the only way to really know if you're meant to be an early bird, as they call it, an early person or a late person, or somewhere in between, is to get morning sunlight and figure out whether or not that makes you feel better.
[00:14:05.960 --> 00:14:12.920] So, what should people do in the afternoon/slash evening time in terms of their light viewing behavior?
[00:14:12.920 --> 00:14:17.840] I mean, the best thing to do is to let the natural light creep in into darkness, right?
[00:14:17.840 --> 00:14:19.360] That would be the best.
[00:14:14.760 --> 00:14:21.760] But clearly, that would be inefficient.
[00:14:21.840 --> 00:14:28.160] You want to go home, you want to read, you want to talk to your kids, you want to talk to your family.
[00:14:28.160 --> 00:14:30.720] So, I think, you know, it's nice to extend the day.
[00:14:30.720 --> 00:14:36.960] I don't think that's wrong if you somehow can block that light from affecting your circadian clock.
[00:14:36.960 --> 00:14:40.400] You do keep your home quite dim to dark at night.
[00:14:40.400 --> 00:14:43.040] I am an extreme, but I measured it for myself.
[00:14:43.040 --> 00:14:45.600] And I asked Reiji, my wife, if she's okay with it.
[00:14:45.600 --> 00:14:46.880] She also liked the dimness.
[00:14:46.880 --> 00:14:49.840] Both of us can see well in dim conditions.
[00:14:49.840 --> 00:14:52.000] But I think you have to measure it for yourself.
[00:14:52.000 --> 00:14:54.080] You really have to do it.
[00:14:54.080 --> 00:14:55.680] It's a very simple experiment.
[00:14:55.680 --> 00:14:58.240] Just try to dim the light as much as you can.
[00:14:58.480 --> 00:15:03.280] I call it the minimum amount of light you require to see comfortably.
[00:15:03.280 --> 00:15:08.480] You know, use red light that is very dim if you want to keep the room for sleeping.
[00:15:08.800 --> 00:15:15.200] Red light that is very dim has very small effect on circadian clock.
[00:15:15.200 --> 00:15:19.440] And below 10 lux of red light literally doesn't affect sleep at all.
[00:15:19.440 --> 00:15:21.360] So there are ways to do it.
[00:15:21.360 --> 00:15:25.760] I've seen you check your phone after dark once or twice.
[00:15:26.160 --> 00:15:30.640] And you did it by sort of pointing your phone away from you, right?
[00:15:30.640 --> 00:15:34.320] It actually makes sense that, you know, if you shine a flashlight in your eye, it's much brighter than if you're lighter.
[00:15:34.560 --> 00:15:36.160] Light can only go in direct line.
[00:15:36.240 --> 00:15:40.480] So if you just look on the side, most of the light is going to go this way and you're only seeing this.
[00:15:41.040 --> 00:15:44.720] And even when I check, sometimes I check it so fast and switch it off so fast.
[00:15:44.720 --> 00:15:47.840] So ideally, I should not check iPhones and iPads.
[00:15:47.840 --> 00:15:53.040] I don't use iPad at night because it's hard to lower it enough because it's a huge.
[00:15:53.040 --> 00:15:56.240] But even my iPhone, I try not to use it at night.
[00:15:56.240 --> 00:16:16.840] You had what I consider absolutely landmark, beautiful paper published in Nature a few years ago, showing that if you disrupt the exposure to light or the timing of the exposure to light, that there are dramatic effects on the stress system and on the learning and memory system.
[00:16:16.840 --> 00:16:31.000] So, if I interpret that correctly, that could mean that when we view light and how much light could make us feel happier or less happy or even depressed, stressed, learning, et cetera.
[00:16:31.320 --> 00:16:31.960] Bingo.
[00:16:32.280 --> 00:16:35.800] Even if we're sleeping and waking up at the appropriate time.
[00:16:35.800 --> 00:16:36.440] Bingo.
[00:16:36.440 --> 00:16:44.680] I mean, eventually, because we're talking about the whole system, eventually when you start having the other problems, you also develop sleep problems.
[00:16:44.680 --> 00:16:46.120] But you're absolutely right.
[00:16:46.120 --> 00:16:55.000] And in fact, now, research from Diego Fernandez in the lab have found that now we know that they actually require different brain regions.
[00:16:55.000 --> 00:17:01.160] So we don't only have a theory, we don't only have a light environment that showed they can be dissociated.
[00:17:01.160 --> 00:17:04.120] We know that they use completely different brain regions.
[00:17:04.120 --> 00:17:19.000] So the SCN that I told you about earlier, the place where the central pacemaker is, the one that receives direct input from the retina through the IPRGCs to adjust your circadian clock, is not the area that receives the light input for mood regulation.
[00:17:19.000 --> 00:17:20.920] It's a completely different brain region.
[00:17:20.920 --> 00:17:38.920] And what's really amazing, this region also receives direct input from the IPRGCs, but projects to areas in the brain that are known to regulate mood, including the ventral, medial, prefrontal, prefrontal cortex, which has been studied for many years to be impacted in a human depression.
[00:17:38.920 --> 00:18:01.120] So, just by this amazing serendipity to find that a region that is so deep in the advanced brain, like the prefrontal cortex is your executive brain, one of the most elaborated in humans, to see that they receive input from these ancient photoreceptors was stunning to us.
[00:18:01.120 --> 00:18:06.800] How does that find inform daily protocols for you or for other people?
[00:18:06.800 --> 00:18:15.360] So, that's why we came up with the tripartite model, because as a circadian biologist, I only thought of light through the circadian clock affecting behavior.
[00:18:15.360 --> 00:18:21.040] As a sleep biologist, they only thought of the homeostatic drive affecting sleep, affecting behavior.
[00:18:21.040 --> 00:18:26.160] And for people who study light for vision and other functions, they thought only of the environmental input.
[00:18:26.160 --> 00:18:33.440] But now, if you put them all together, you get with this tripartite model where it's really mind-boggling and it makes so much sense.
[00:18:33.440 --> 00:18:43.120] The organism doesn't want to depend on a single component, but if you could incorporate these three together, you could have a beautiful system that is well adapted.
[00:18:43.120 --> 00:18:45.440] So, let me tell you the sleep-wake cycle, right?
[00:18:45.440 --> 00:18:48.800] So, we know there is a homeostatic drive to affect sleep.
[00:18:48.800 --> 00:18:51.040] We've had beautiful talks about that.
[00:18:51.040 --> 00:18:53.520] Which is basically the longer you're awake, the more you want to be asleep.
[00:18:53.600 --> 00:18:55.440] So, that's your homeostatic drive.
[00:18:55.440 --> 00:19:03.200] We've talked about the circadian influence of sleep and the fact that light-dark cycles affect the circadian system, which eventually affects sleep.
[00:19:03.200 --> 00:19:05.360] So, these two components are well understood.
[00:19:05.360 --> 00:19:09.280] Now, the third factor is your direct light or environmental input.
[00:19:09.280 --> 00:19:14.000] How much stress, how much light you get from there also can highly impact sleep.
[00:19:14.000 --> 00:19:24.160] So, even if you have a good circadian and homeostatic drive, if you're getting light at the wrong time of the day, or if you're being stressed and thinking, then your sleep is going to suffer.
[00:19:24.160 --> 00:19:29.800] So, you have to think of the three together to have a beautiful sleep-wake cycle.
[00:19:29.800 --> 00:19:33.720] Let's talk about food and eating and appetite.
[00:19:29.440 --> 00:19:35.560] You had yet another.
[00:19:37.160 --> 00:19:40.840] Yes, I greatly admire your success in this way.
[00:19:40.840 --> 00:19:50.280] Yet another incredible discovery showing that there are direct effects of light on appetite and feeding behavior.
[00:19:50.280 --> 00:20:00.120] So for somebody who's interested in affecting their eating behavior, how should they use light in order to adjust their eating behavior?
[00:20:00.120 --> 00:20:00.760] Right.
[00:20:00.760 --> 00:20:09.160] So now that I've told you about all these interactions between the different inputs to the circadian clock, just you think about it as an engineer.
[00:20:09.160 --> 00:20:10.600] What would be the best thing?
[00:20:10.600 --> 00:20:20.920] The best thing is to know when your food times happen in the day, when you should get light, and where is your circadian, when is your circadian clock in your system, right?
[00:20:21.560 --> 00:20:29.880] So if you eat at very specific times of the day, that's another signal that is telling your body, your clock, you're in a certain time of the day.
[00:20:29.880 --> 00:20:37.400] So if you're having lunch at the correct time every day and you're getting bright light, now you have two systems that are informing your clock.
[00:20:37.400 --> 00:20:38.920] Your clock is going to be better.
[00:20:38.920 --> 00:20:40.360] So regular meal times.
[00:20:40.360 --> 00:20:43.560] Regular meantimes that fit your circadian clock.
[00:20:43.560 --> 00:20:53.400] So, and in fact, if you do that, when I started doing this and it helped me lose weight, is that I'm exposing myself to the right amount of light, dark cycle.
[00:20:53.400 --> 00:20:55.240] I'm eating at regular time.
[00:20:55.240 --> 00:20:56.360] It is amazing.
[00:20:56.360 --> 00:20:57.480] You will be not hungry.
[00:20:57.480 --> 00:20:59.080] Let's say, let's say you eat at noon.
[00:20:59.080 --> 00:21:01.960] You will not feel any hunger at 11:45.
[00:21:01.960 --> 00:21:04.600] And then all of a sudden, the hunger jumps in.
[00:21:04.600 --> 00:21:08.680] This is clearly not an energy issue because it could not be that drastic.
[00:21:08.680 --> 00:21:08.840] Right.
[00:21:08.840 --> 00:21:21.520] No, the desire to eat is mainly driven by these cues, these hormone cues that are very exquisitely timed to sleep-wake cycle, but also to light.
[00:21:21.760 --> 00:21:22.560] Exactly.
[00:21:22.560 --> 00:21:27.200] How regular are you, or do you recommend people be about meal times?
[00:21:27.200 --> 00:21:28.880] Are we talking about down to the minute?
[00:21:28.880 --> 00:21:37.280] Like, if I absolutely, all right, plus or so, 12:00 is my normal lunch, let's say, uh, plus or minus half an hour.
[00:21:37.280 --> 00:21:40.880] Okay, yeah, so eat around between 11:30 and 12:30.
[00:21:40.880 --> 00:21:44.640] If that's the time, and it depends if you also do multiple meals.
[00:21:44.640 --> 00:21:48.480] Remember, three meals-that's a decision that somebody came up with.
[00:21:48.480 --> 00:21:49.280] I don't know why.
[00:21:49.280 --> 00:21:51.440] Nowadays, people are fewer people are doing that, I think.
[00:21:51.440 --> 00:21:54.400] Yeah, given our friends such in Panda's work, right?
[00:21:54.400 --> 00:22:02.880] I mean, so you could have two meals, you could have very multiple meals that are distributed across your active time.
[00:22:02.880 --> 00:22:11.520] Some people are not hungry early in the day, they might be late-shifted people, in which case, eating later in the day will work well for them as long as they don't eat early in the morning.
[00:22:11.520 --> 00:22:15.520] That's just you have to work with your schedule, with your active schedule.
[00:22:15.520 --> 00:22:25.360] What we're talking about really is finding your ideal sleep schedule and finding your ideal eating schedule and understanding how those two things interact.
[00:22:25.360 --> 00:22:38.480] And you know, the nice thing, as you said, finding them out is going to help you to understand how they interact because we know from the tripartite model that they are all interconnected, and for each person, they're going to be interconnected differently.
[00:22:38.480 --> 00:22:53.760] It's striking to me that in all animals, besides humans, if they deviate too much from the appropriate exposure to light and light-dark cycle, they essentially don't mate and/or die and/or get killed off.
[00:22:53.760 --> 00:22:58.160] But in humans, we are able to override that at least to some extent.
[00:22:58.160 --> 00:23:12.680] But the ways in which we suffer appear to be things like obesity, metabolic syndromes, reproductive syndromes that accompany the other syndromes, you know, endocrine syndromes, and mood and depressive disorders.
[00:23:12.680 --> 00:23:23.960] Is there any effort at the level of the nationally or laboratories that you're aware of to try and use light in order to improve mood and mental health?
[00:23:23.960 --> 00:23:26.120] I mean, honestly, this is my moonshot.
[00:23:26.120 --> 00:23:32.360] This is the thing that I think people, because it's, I say, don't take a pill, take a photon.
[00:23:32.360 --> 00:23:34.600] And not, I mean, you take pills, it's important.
[00:23:34.600 --> 00:23:57.240] I'm just making it that really we have an opportunity right now with the incredible advances of LED lights, of changing spectra of light, of regulating intensities, and just to associate, just for simple changes, you could really improve sleep-wake cycle, productivity, and still, you could actually get more done.
[00:23:57.240 --> 00:24:06.440] Because, as we've talked about, when you have all these messed up, now you have to sleep more, but your sleep is fragmented, it's not very good, and you can't focus.
[00:24:06.680 --> 00:24:10.920] And you can't focus when you don't have alertness when you need the alertness.
[00:24:10.920 --> 00:24:16.760] So, having all these could allow you to do even more actually at the end than less.
[00:24:16.760 --> 00:24:19.480] And that's the exciting part of it.
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[00:25:42.480 --> 00:25:44.880] Let's talk about jet lag.
[00:25:45.120 --> 00:25:50.080] What are the two or three things that people can do to adjust their schedule quickly?
[00:25:50.080 --> 00:25:55.280] Like, let's say fall classes are starting, you start a new job, or you have a baby or a puppy or whatever.
[00:25:55.280 --> 00:25:58.000] What is the best way to shift the clock quickly?
[00:25:58.000 --> 00:26:00.400] So, it's very simple, as we've talked yesterday.
[00:26:00.400 --> 00:26:06.480] So, imagine you're in the outside with no environmental, with no industrial light.
[00:26:07.280 --> 00:26:12.720] If your body thinks you're in early evening and you see a bright light, what does this tell you?
[00:26:12.720 --> 00:26:15.440] Oh, wait, this is not early evening yet.
[00:26:15.440 --> 00:26:18.880] It's still early afternoon or late afternoon.
[00:26:18.840 --> 00:26:22.880] So, so I have to delay my clock to go back to late afternoon.
[00:26:22.880 --> 00:26:27.680] So, if you get light early in the evening, it delays your clock.
[00:26:27.680 --> 00:26:30.000] So, what does that make you want to go to sleep later?
[00:26:30.600 --> 00:26:31.880] Yes, it delays your clock.
[00:26:31.880 --> 00:26:43.480] So later in the night, later in your night, and actually, it just happens that in humans, you get a temperature in the deer later in the night, low temperature in your body.
[00:26:43.480 --> 00:26:46.760] After that, lights start advancing your clock.
[00:26:46.760 --> 00:26:57.800] If I understand correctly, what you're saying is if your typical wake-up time is, say, 7 a.m., then your low point in temperature probably occurs somewhere around 5 a.m.
[00:26:58.600 --> 00:27:03.800] And if you view light right around then, it's going to essentially advance your clock.
[00:27:03.800 --> 00:27:09.320] Yeah, because then your body thinks, oh, it's seven o'clock, so advance your clock by one to two hours.
[00:27:09.320 --> 00:27:15.080] But if I were to view light, say at 3 a.m., then it would probably delay my clock.
[00:27:15.080 --> 00:27:15.480] Yeah.
[00:27:15.480 --> 00:27:16.120] Okay.
[00:27:16.120 --> 00:27:16.520] Yeah.
[00:27:16.680 --> 00:27:19.400] So, and then let's say I land in a new schedule.
[00:27:19.560 --> 00:27:20.680] I want to adjust to a new schedule.
[00:27:20.680 --> 00:27:25.800] Let's say I didn't manage to do anything with my light viewing before I went and I didn't do it, I didn't anticipate the trip.
[00:27:25.800 --> 00:27:27.560] Suddenly, I'm on a new schedule.
[00:27:27.560 --> 00:27:28.120] Okay.
[00:27:28.440 --> 00:27:44.440] I was told that one of the ways to help shift the clock and to avoid gastrointestinal issues is to eat on the local schedule to start basically behaving like a local, even though your circadian clock will take a little bit of time to catch up.
[00:27:44.440 --> 00:27:45.240] Absolutely.
[00:27:45.240 --> 00:27:47.640] But you have to remember the light, right?
[00:27:47.640 --> 00:27:52.760] So let's now that we explained it very simply, let's take a very simple example, right?
[00:27:53.080 --> 00:27:54.440] New York to Italy.
[00:27:54.440 --> 00:27:56.120] That's a simple example.
[00:27:56.120 --> 00:27:59.080] New York time, Italy time, six-hour difference, right?
[00:27:59.080 --> 00:28:04.280] So let's say you fly from New York at night, you reach Italy at eight o'clock in the morning.
[00:28:04.280 --> 00:28:06.760] What is the time in your New York time?
[00:28:07.080 --> 00:28:10.520] Although you reach six hours back, six hours back, it's 2 a.m.
[00:28:10.760 --> 00:28:14.440] So when you land Italy, you want to avoid light like the plague.
[00:28:14.440 --> 00:28:17.200] Yeah, you could eat, but you really don't want to get alive.
[00:28:17.200 --> 00:28:18.480] Right, because otherwise it's going to delay you.
[00:28:18.720 --> 00:28:22.080] That delay is going to send you to California instead of sending you to Italy.
[00:28:14.840 --> 00:28:22.160] Right.
[00:28:22.240 --> 00:28:24.640] What Sam was saying is so crucial.
[00:28:24.960 --> 00:28:34.720] Just because getting bright light in your eyes early in the day is really beneficial when you're at home, when you travel to a new time zone, you have to take into account where your body thinks you are.
[00:28:34.720 --> 00:28:43.440] And so if you're looking at the Italian sunrise, having just flown from New York to Italy, and you didn't prepare for that trip by waking up a little bit earlier in anticipation, multiple days.
[00:28:43.600 --> 00:28:45.200] And you view light at 2 a.
[00:28:45.360 --> 00:28:47.680] excuse me, at 6 or 7 a.m.
[00:28:47.920 --> 00:28:52.320] Italian time, beautiful Italian sunrise, you are going to delay your clock.
[00:28:52.320 --> 00:28:56.320] You're going to basically throw yourself back to California, but you are in Italy.
[00:28:56.320 --> 00:29:03.440] You're going to throw your biology back to California and you are going to be up in the middle of the Italian night and you're going to be miserable.
[00:29:03.760 --> 00:29:13.600] It's very important to avoid getting the wrong light information when you're trying to adjust your body because otherwise it shifts you to the other cycle.
[00:29:13.600 --> 00:29:14.720] Absolutely, right?
[00:29:15.040 --> 00:29:17.760] You are one of these people that has such vigor.
[00:29:17.760 --> 00:29:33.520] I think a lot of your ability to work hard and focus and really do so many things at an impressive level is because you think about these issues and you think about when you're going to be optimal for focus, when you're going to be optimal for exercise, when, and the when is the key.
[00:29:34.080 --> 00:29:38.960] And I think a lot of people live in the landscape of feeling like there's something broken inside them.
[00:29:38.960 --> 00:29:49.200] I really agree with you that I think part of the reason I'm continuing to be able to do this, that I really think about it and I make sure that I keep everything aligned.
[00:29:49.200 --> 00:29:51.360] And that actually helps me a lot.
[00:29:51.360 --> 00:29:53.600] Like, I don't suffer in sleep.
[00:29:53.600 --> 00:29:54.960] I don't suffer in waking up.
[00:29:54.960 --> 00:29:57.040] I never use a timer to wake up.
[00:29:57.200 --> 00:29:58.960] System is so aligned.
[00:29:58.960 --> 00:30:00.040] It works.
[00:29:59.520 --> 00:30:06.600] A lot of times, people will say, How come I go to sleep, I fall asleep fine, but then I wake up at three or four in the morning and can't fall back asleep.
[00:30:07.080 --> 00:30:10.520] Is it possible that those people were supposed to go to bed at 8 p.m.?
[00:30:10.520 --> 00:30:21.240] Yeah, I mean, it is possible, or it's possible that their clock is completely misaligned, that they are getting maybe enough time at night when they are supposed, and then they possibly feel so sleepy in the day.
[00:30:21.240 --> 00:30:23.560] So, there, all these are possible combinations.
[00:30:23.560 --> 00:30:24.520] Well, that's an interesting idea.
[00:30:24.520 --> 00:30:31.480] I hadn't considered so that what they think is their sleep, their body is so out of whack with the light-dark cycle that it's actually a nap.
[00:30:31.480 --> 00:30:33.880] A nap or the weaker part of the sleep.
[00:30:33.880 --> 00:30:39.000] I mean, you see this in when you travel to different time zone before you adjust.
[00:30:39.000 --> 00:30:43.080] You go to sleep really well, but two hours later, you're fully up.
[00:30:43.080 --> 00:30:44.120] Two hours.
[00:30:44.120 --> 00:30:49.720] If you were so tired and this is your regular sleep, there's no way you're gonna wake up in two hours.
[00:30:49.720 --> 00:30:52.200] Let's talk about seasonality a little bit.
[00:30:52.200 --> 00:30:56.120] Are there other effects of seasonality on humans that we are aware of?
[00:30:56.120 --> 00:31:00.120] Honestly, you could see it perfectly, I think, in Scandinavia.
[00:31:00.120 --> 00:31:04.920] I mean, you could talk to people who live in sure they get seasonal depression.
[00:31:04.920 --> 00:31:15.400] What seasonal depression is one, but actually, when you start asking them questions, they tell you like in the winter, they barely could wake up, they barely have the energy before even depression.
[00:31:15.400 --> 00:31:23.080] Even people who don't get seasonal depression, they'll tell you our energy level is lower, our ability to go to work is not the same.
[00:31:23.080 --> 00:31:26.760] And in the summer, most people actually sleep very little.
[00:31:26.760 --> 00:31:35.480] They tell you we really can feel like we're manic, we have all this energy, and not in a negative way, in a funny way, right?
[00:31:35.480 --> 00:31:38.840] I mean, but if you want to sleep, we have to put this curtain.
[00:31:38.840 --> 00:31:44.280] I think in these situations, you could really appreciate the seasonality of humans.
[00:31:44.520 --> 00:31:51.600] I think we kind of destroyed our seasonality because we don't get exposed to that much natural light.
[00:31:51.600 --> 00:31:53.280] We have all this artificial light.
[00:31:53.280 --> 00:32:06.640] But I think, honestly, one of the things that is going to happen if they follow your recommendation, this is going to cause them to also experience some changes across the season because now they're going to see the sun differently.
[00:32:06.640 --> 00:32:11.200] If you're going to go out in the morning in the summer, you're going to get a much brighter time.
[00:32:11.200 --> 00:32:12.960] That's why I don't like the change in time.
[00:32:12.960 --> 00:32:15.680] I know people think, oh, because you're biased.
[00:32:16.160 --> 00:32:19.920] Because I think sorry, the change in are you talking about daylight savings?
[00:32:19.920 --> 00:32:20.720] Daylight saving.
[00:32:20.720 --> 00:32:25.760] It's such a bad idea because it disrupts that rhythm that you're having.
[00:32:25.760 --> 00:32:30.480] Because I think your body, if you keep that rhythm, you will see the whole seasonality.
[00:32:30.480 --> 00:32:33.840] And I look at it from a different aspect than other people.
[00:32:33.840 --> 00:32:48.800] If you think about it, Andrew, there is a situation where you're getting light perfectly well, and then all of a sudden they delay it by one hour because, and then even though it's the summer, your body now, if you're still not adjusting, think, oh, wait, what happened?
[00:32:48.800 --> 00:32:49.840] What kind of happened?
[00:32:49.840 --> 00:32:54.480] Well, I'm glad you're bringing this up because I always thought, you know, what's the big deal?
[00:32:54.480 --> 00:32:55.520] One hour, right?
[00:32:55.520 --> 00:32:57.520] One hour shift, you know, spring forward fallback.
[00:32:57.760 --> 00:32:59.440] Adjust one hour actually.
[00:32:59.440 --> 00:33:03.040] But the, but this goes back to the beginning of our discussion.
[00:33:03.040 --> 00:33:04.640] It's not just one hour.
[00:33:04.640 --> 00:33:05.120] Right.
[00:33:05.120 --> 00:33:14.080] Because it's one hour across that one day, but there's this cumulative effect on the clock and these three elements of your tripartite model, right?
[00:33:14.160 --> 00:33:17.360] The homeostatic sleep and the light direct effects on mood.
[00:33:17.360 --> 00:33:26.000] And when it's so close, it's sometimes hard to figure out how to adjust it perfectly because, you know, we're already sleep-deprived in our society.
[00:33:26.000 --> 00:33:32.200] And then you shift it by, you know, so it just, it all accumulates and it has no benefit.
[00:33:32.200 --> 00:33:34.200] I just don't understand why they do this.
[00:33:29.840 --> 00:33:35.160] It makes no sense.
[00:33:35.480 --> 00:33:40.440] Well, I think that the reason they do it is because they don't understand the biology.
[00:33:40.440 --> 00:33:46.680] Because one hour seems trivial unless you understand the repercussions of that one-hour shift.
[00:33:46.680 --> 00:33:57.000] Because what's also clear now, based on what you're saying, is that that one-hour shift is taking you out of alignment with the natural light-dark cycle in exactly the wrong direction.
[00:33:57.000 --> 00:34:03.080] It's pushing people to get even later in the summer when light is going to push you later anyway.
[00:34:03.080 --> 00:34:07.000] It's really compounding the problem that already exists.
[00:34:07.000 --> 00:34:13.160] Samer, this has been an amazing march through the importance of light.
[00:34:13.160 --> 00:34:23.720] I'm certain that people are going to start thinking about how to change their relationship with light as a way to anchor everything that they do and that's important to their health.
[00:34:23.720 --> 00:34:25.640] Let's talk a little bit about where people can find you.
[00:34:25.640 --> 00:34:28.280] Your laboratory is at the National Institutes of Mental Health.
[00:34:28.280 --> 00:34:32.200] He is head of the chronobiology unit, all these things that I've mentioned earlier.
[00:34:32.200 --> 00:34:35.560] But you are active on Twitter and Instagram.
[00:34:35.560 --> 00:34:35.880] Right.
[00:34:35.880 --> 00:34:37.960] So, what is your Twitter handle?
[00:34:37.960 --> 00:34:39.640] It's at Samur Hattar.
[00:34:39.640 --> 00:34:41.320] And I think the same for Instagram.
[00:34:41.320 --> 00:34:44.440] So, definitely give him a follow there and on Twitter.
[00:34:44.440 --> 00:34:54.120] And I'm sure that he'll be happy to answer questions and entertain any and all discussions about chronobiology.
[00:34:54.120 --> 00:34:54.760] Absolutely.
[00:34:54.760 --> 00:34:55.160] Yeah.
[00:34:55.160 --> 00:34:56.360] And light.
[00:34:56.360 --> 00:34:56.840] Yeah.
[00:34:57.400 --> 00:34:57.720] Great.
[00:34:57.720 --> 00:34:58.680] Thank you, Samer.
[00:34:58.680 --> 00:34:59.000] Awesome.
[00:34:59.000 --> 00:35:00.360] Thank you, Rank.